Attenuated Structural Transformation of Aconitine during Sand Frying Process and Antiarrhythmic Effect of Its Converted Products

Table 3

¹H (600 MHz) and¹³C (150 MHz) NMR data of compound 1.

Position	1					Aconitine
	δH (J in Hz)	δC	HMBC	NOESY	^1H–^1H COSY	δC
1	3.06 m	83.5 d	C-10, C-17, 1-OCH3	H-3, H-5, H-10, 1-OCH3	H-2α, β	83.4 d
2α	2.32 m	34.2 t	C-4, C-11	——	H-1, H-2β, H-3	34.1 t
2β	2.18 m		C-4, C-11	——	H-1, H-2α, H-3
3	3.68 m	71.5 d	C-1, C-18, C-19	H-1, H-5	H-2α, β	70.4 d
4	——	43.5 s	——	——	——	43.2 s
5	2.03 d (6.6)	48.1 d	C-3, C-7, C-10, C-17, C-18, C-19	H-1, H-3, H-18α, β	H-6	46.6 d
6	3.92 d (6.6)	84.1 d	C-4, C-8, C-17, 6-OCH3	H-8, 6-OCH3	H-5, H-7	82.3 d
7	2.73 m	42.5 d	C-5, C-9, C-11, C-15	6-OCH3	H-6, H-8	44.8 d
8	2.75 m	48.5 d	C-10, C-15, C-17	H-6, H-2′, 6′	H-7, H-9	92.0 s
9	2.78 m	38.6 d	C-12, C-13, C-15	——	H-8, H-10, H-14	44.2 d
10	2.15 m	43.1 d	C-5, C-8, C-17	H-1, H-14	H-9, H-12α, β	40.8 d
11	——	50.9 s	——	——	——	49.8 s
12α	2.71 m	36.1 t	C-9, C-11, C-13, C-14, C-16	——	H-10, H-12β	36.2 t
12β	2.26 m		C-9, C-11, C-13, C-16	H-14	H-10, H-12α
13	——	76.5 s	——	——	——	74.0 s
14	5.16 d (5.1)	79.6 d	C-8, C-13, C-16, ArC=O	H-10, H-12β	H-9	78.9 d
15	——	211.8 s	——	——	——	78.9 d
16	3.29 s	89.2 d	C-8, C-12, C-14, C-15, 16-OCH3	H-17, 16-OCH3	——	90.1 d
17	2.81 s	61.9 d	C-5, C-6, C-8, C-10, C-19	H-16, H-21	——	61.0 d
18α	3.68 d (9.18)	76.2 t	C-3, C-5, C-19, 18-OCH3	H-5, H-19α, β, 18-OCH3	H-18β	77.1 t
18β	3.75 d (9.18)		C-3, C-5, C-19, 18-OCH3	H-5, H-19α, 18-OCH3	H-18α
19α	2.37 d (10.98)	47.4 t	C-3, C-18, C-21	H-18α, β	H-19β	48.8 t
19β	2.89 d (10.98)		C-3, C-5, C-17	H-18α	H-19α
21α	2.41 m	49.1 t	C-17, C-19	H-17	H-22	46.9 t
21β	2.44 m		C-17, C-19	H-17	H-22
22	1.01 t (7.32)	13.3 q	——	——	H-21α, β	13.3 q
8-C=O	——	——	——	——	——	172.2 s
CH3	——	——	——	——	——	21.3 q
1-OCH3	3.23 s	56.1 q	C-1	H-1	——	55.6 q
6-OCH3	3.27 s	57.9 q	C-6	H-6, H-7	——	59.0 q
16-OCH3	3.61 s	61.7 q	C-16	H-16, H-2′, 6′	——	60.7 q
18-OCH3	3.28 s	59.2 q	C-18	H-18α, ß	——	57.9 q
ArC=O	——	167.1 s	——	——	——	165.9 s
1′	——	129.6 s	——	——	——	129.8 s
2′, 6′	7.94 d (7.32)	129.8 d	C-4′, ArC=O	H-8, 16-OCH3	H-3′, 5′	129.6 d
3′, 5′	7.40 t (7.32)	128.4 d	C-1′, ArC=O	——	H-2′, 6′, H-4′	128.6 d
4′	7.53 t (7.32)	133.3 d	C-2′, 6′	H-3′, 5′	H-3′, 5′	133.2 d