Attenuated Structural Transformation of Aconitine during Sand Frying Process and Antiarrhythmic Effect of Its Converted Products

Table 4

¹H (600 MHz) and¹³C (150 MHz) NMR data of compound 2.

Position	2					Aconitine
	δH (J in Hz)	δC	HMBC	NOESY	^1H–^1H COSY	δC
1	3.05 m	83.6 d	C-10, C-17, 1-OCH3	H-3, H-10, 1-OCH3	H-2α, β	83.4 d
2α	2.36 m	34.1 t	C-4	——	H-1, H-2β, H-3	34.1 t
2β	2.17 m		C-4, C-11	——	H-1, H-2α, H-3
3	3.67 m	71.8 d	C-18, C-19	H-1, H-5	H-2α, β	70.4 d
4	——	43.7 s	——	——	——	43.2 s
5	2.04 d (6.6)	48.5 d	C-3, C-7, C-10, C-17, C-18, C-19	H-3, H-18α, β	H-6	46.6 d
6	3.89 d (6.6)	84.1 d	C-4, C-8, C-17, 6-OCH3	H-8, 6-OCH3	H-5, H-7	82.3 d
7	2.78 m	41.8 d	C-9, C-11, C-15	6-OCH3	H-6, H-8	44.8 d
8	2.65 m	49.4 d	C-10, C-15, C-17	H-6, H-16	H-7, H-9	92.0 s
9	2.80 m	38.7 d	C-12, C-13, C-15	——	H-8, H-10, H-14	44.2 d
10	2.22 m	44.8 d	C-8, C-17	H-1, H-14	H-9, H-12α, β	40.8 d
11	——	51.2 s	——	——	——	49.8 s
12α	3.02 m	32.9 t	C-11, C-13, C-14, C-16	——	H-10, H-12β	36.2 t
12β	1.83 m		C-11, C-13, C-16	H-14	H-10, H-12α
13	——	77.5 s	——	——	——	74.0 s
14	5.41 d (5.16)	78.5 d	C-8, C-13, C-16, ArC=O	H-10, H-12β	H-9	78.9 d
15	——	211.7 s	——	——	——	78.9 d
16	3.85 s	86.1 d	C-12, C-15, 16-OCH3	H-8, H-2′, 6′	——	90.1 d
17	2.98 s	61.6 d	C-1, C-6, C-10, C-19	H-21	——	61.0 d
18α	3.69 d (9.18)	76.8 t	C-3, C-5, C-19, 18-OCH3	H-5, H-19α, β, 18-OCH3	H-18β	77.1 t
18β	3.75 d (9.18)		C-3, C-5, C-19, 18-OCH3	H-5, H-19α, 18-OCH3	H-18α
19α	2.39 d (10.98)	47.4 t	C-3, C-5, C-18, C-21	H-18α, β	H-19β	48.8 t
19β	2.90 d (10.98)		C-3, C-5, C-17	H-18α	H-19α
21α	2.45 m	49.0 t	C-17, C-19	H-17	H-22	46.9 t
21β	2.52 m		C-17, C-19	H-17	H-22
22	1.04 t (7.38)	13.3 q	——	——	H-21α, β	13.3 q
8-C=O	——	——	——	——	——	172.2 s
CH3	——	——	——	——	——	21.3 q
1-OCH3	3.24 s	56.1 q	C-1	H-1	——	55.6 q
6-OCH3	3.24 s	57.8 q	C-6	H-6, H-7	——	59.0 q
16-OCH3	3.80 s	62.3 q	C-16	——	——	60.7 q
18-OCH3	3.29 s	59.2 q	C-18	H-18α, β	——	57.9 q
ArC=O	——	166.1 s	——	——	——	165.9 s
1′	——	129.4 s	——	——	——	129.8 s
2′, 6′	7.97 d (7.32)	129.7 d	C-4′, ArC=O	H-16	H-3′, 5′	129.6 d
3′, 5′	7.46 t (7.32)	128.6 d	C-1′, ArC=O	——	H-2′, 6′, H-4′	128.6 d
4′	7.60 t (7.32)	133.6 d	C-2′, 6′	H-3′, 5′	H-3′, 5′	133.2 d