Attenuated Structural Transformation of Aconitine during Sand Frying Process and Antiarrhythmic Effect of Its Converted Products

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Compound</td><td class="align_center">Dose (mg/kg)</td><td class="align_center">VPB incubation period (s)</td><td class="align_center">VT incidence (%)</td><td class="align_center">Mortality (%)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Aconitine</td><td class="align_center">0.03</td><td class="align_center">97.7 ± 23.7</td><td class="align_center">100</td><td class="align_center">0</td></tr><tr><td class="align_left">16-Epi-pyroaconitine</td><td class="align_center">0.03</td><td class="align_center">—</td><td class="align_center">0</td><td class="align_center">0</td></tr><tr><td class="align_left" rowspan="2">Pyroaconitine</td><td class="align_center">0.03</td><td class="align_center">—</td><td class="align_center">0</td><td class="align_center">0</td></tr><tr><td class="align_center">0.13</td><td class="align_center">134.1 ± 36.5</td><td class="align_center">80</td><td class="align_center">10</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>“—” means that no arrhythmias occurred within 30 min after the injection of the experimental compounds.<br/></div></td></tr></table>

<div>Comparison of cardiotoxicity between aconitine and its converted products (mean ± SD).</div>

Evidence-Based Complementary and Alternative Medicine

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Table 5

Table 5: Attenuated Structural Transformation of Aconitine during Sand Frying Process and Antiarrhythmic Effect of Its Converted Products 