Comparison of Pharmacokinetics and Tissue Distribution Characteristics of Three Diterpenoid Esters in Crude and Prepared Semen Euphorbiae

Table 9

Main pharmacokinetic parameters of the three analytes in the plasma of rats after the oral administration of SE or SEP extract (n = 6).

Data	Euphorbia factor L1		Euphorbia factor L2		Euphorbia factor L3
	SE	SEP	SE	SEP	SE	SEP
AUC (0-t) (μg·h·L^−1)	1703.73 ± 554.18	1391.45 ± 663.03	4391.97 ± 1596.69	3192.79 ± 1409.02	6381.91 ± 1428.34	4100.05 ± 1741.94
AUC (0-∞) (μg·h·L^−1)	2883.63 ± 2458.81	1416.66 ± 662.13	5382.56 ± 1370.29	3230.99 ± 1415.46	9463.33 ± 6415.46	4208.31 ± 1769.18
MRT (0-t) (h)	17.80 ± 2.16	16.78 ± 3.56	17.04 ± 4.18	15.71 ± 2.18	18.83 ± 2.33	16.10 ± 2.56
MRT (0-∞) (h)	22.57 ± 3.87	17.79 ± 3.92	21.73 ± 4.31	16.29 ± 2.42	24.47 ± 7.51	17.50 ± 3.27
T1/2z (h)	9.53 ± 6.43	8.42 ± 2.67	9.57 ± 4.32	7.42 ± 1.05	9.35 ± 4.91	8.46 ± 2.19
Tmax (h)	11.33 ± 1.63	6.67 ± 2.07	11.33 ± 1.63	8.00 ± 2.53	11.33 ± 1.63	8.00 ± 2.53
Vz/F (L·kg^−1)	220467.01 ± 146342.43	345882.41 ± 248756.73	85495.40 ± 51708.11	117516.85 ± 57982.30	61277.19 ± 49305.43	108497.33 ± 83949.46
CLz/F L·(h·kg^−1)	15457.44 ± 8978.23	27871.15 ± 18174.36	5927.25 ± 1697.04	10922.36 ± 5049.21	3993.88 ± 1591.83	8591.23 ± 4521.52
Cmax (μg·L^−1)	102.68 ± 34.75	91.39 ± 47.39	281.32 ± 105.93	218.53 ± 111.66	381.33 ± 139.59	327.20 ± 147.33

SE group compared with SEP group, ^∗, ^∗∗.