Review Article

Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

Table 3

Top 10 KEGG pathways of hub genes.

TermCount% valueGenes

Pathways in cancer1661.543.36E-13JUN, SMAD3, CXCL8, STAT1, FOS, EGFR, RELA, VEGFA, IL6, MAPK8, PIK3CA, MYC, AKT1, MAPK1, CTNNB1, and TP53
Chagas disease1453.854.42E-18JUN, SMAD3, CXCL8, FOS, MAPK14, TNF, IL2, RELA, IL6, MAPK8, PIK3CA, IL1B, AKT1, and MAPK1
Hepatitis B1453.853.88E-16JUN, CXCL8, STAT1, SRC, FOS, TNF, RELA, IL6, MAPK8, PIK3CA, MYC, AKT1, MAPK1, and TP53
Toll-like receptor signaling pathway1350.004.12E-16JUN, CXCL8, STAT1, FOS, MAPK14, TNF, RELA, IL6, MAPK8, PIK3CA, IL1B, AKT1, and MAPK1
Influenza A1350.001.84E-13JUN, CXCL8, STAT1, MAPK14, TNF, RELA, IL6, MAPK8, PIK3CA, IL1B, AKT1, MAPK1, and JAK2
Proteoglycans in cancer1246.152.98E-11PIK3CA, SRC, MYC, MAPK1, CTNNB1, AKT1, MAPK14, ESR1, TNF, TP53, EGFR, and VEGFA
MAPK signaling pathway1246.153.79E-10JUN, MAPK8, MYC, IL1B, MAPK1, AKT1, FOS, MAPK14, TNF, TP53, RELA, EGFR
HTLV-I infection1246.153.96E-10IL6, JUN, SMAD3, PIK3CA, MYC, CTNNB1, AKT1, FOS, TNF, TP53, RELA, and IL2
PI3K-Akt signaling pathway1246.151.02E-08IL4, IL6, PIK3CA, MYC, MAPK1, AKT1, JAK2, TP53, RELA, EGFR, IL2, and VEGFA
Prolactin signaling pathway1142.312.05E-14MAPK8, PIK3CA, STAT1, SRC, MAPK1, AKT1, FOS, JAK2, MAPK14, ESR1, and RELA