Based on Network Pharmacology to Explore the Potential Bioactive Compounds and Mechanisms of Zuojin Pill for the Treatment of Ulcerative Colitis

Table 5

Toxicity prediction of 14 active components in ZJP.

Code name	Molecule name	Ames mutagenesis	Hepatotoxicity	Acute oral toxicity	Acute oral toxicity evaluation
CR1	Berberine	−−−	++	551.84 mg/kg	Low
CR2	Obacunone	−−	+	51.827 mg/kg	Toxicity
CR3	Quercetin	++	+	698.794 mg/kg	Low
C1	Worenine	−	+	558.731 mg/kg	Low
C2	Coptisine	−	−	547.759 mg/kg	Low
C5	Epiberberine	−−−	++	571.233 mg/kg	Low
C7	Berberrubine	−−−	++	301.519 mg/kg	Toxicity
C8	Palmatine	−	++	660.767 mg/kg	Low
C9	Palmidin A	+	−−−	147.569 mg/kg	Toxicity
C10	Moupinamide	−	++	1603.37 mg/kg	Low
R48	Beta-sitosterol	−−−	−−−	273.371 mg/kg	Toxicity
R78	Isorhamnetin	−−−	+	604.02 mg/kg	Low
R102	Rutaecarpine	−−−	++	624.265 mg/kg	Low
R103	Rutalinidine	−	+++	591.306 mg/kg	Low

Note. The “+” and “−” represent the predicted toxicity possibility. 0.1(−−−); 01–0.3(−−); 0.3–05(−); 0.5–0.7(+); 0.7–0.9(++); 0.9–10(+++). Acute oral toxicity evaluation involves high toxicity (1∼50 mg/kg), toxicity (51∼500 mg/kg), and low toxicity (501∼5000 mg/kg). C: Rhizoma Coptidis components; R: Fructus Evodiae components; C&R: Rhizoma Coptidis and Fructus Evodiae shared components.