Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/β-Catenin Signaling through Downregulating miR-15-5p

Figure 4

Nobiletin significantly inhibited cancer stemness and WNT/β-catenin signaling in NSCLC cells. (a) The effect of nobiletin on NSCLC cell stemness was investigated using a sphere formation assay. (b) The effect of nobiletin on NSCLC cell stemness was investigated by measuring cancer stemness marker protein expression by western blot. (c) The effect of nobiletin on WNT/β-catenin signaling was investigated by measuring β-catenin expression by IF. (d) The effect of nobiletin on WNT/β-catenin signaling was investigated by measuring the downstream gene expression of β-catenin signaling by western blot.