Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways

<div>EA regulates the expression level of hepatic inflammation pathway-related proteins detected by Western blot. There are 10 rats in the normal group and 9 rats in each of no-intervention group (CCl4) and treatment groups including EA group (CCl4 + EA), lactulose group (CCl4 + Lac), and EA combined with lactulose (CCl4 + CM) group. (a) The protein expression of TNF-α and IL-6. (b) TLR4 pathway-associated signal proteins TLR4, MyD88, and NF-κB. (c) Proteins expressions of phosphorylated and total p38MAPK and STAT3.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 7: Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways

Figure 7 | Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways 