Hypermethylation of DLG3 Promoter Upregulates RAC1 and Activates the PI3K/AKT Signaling Pathway to Promote Breast Cancer Progression

<div>Inhibition of the PI3K/AKT pathway by DLG3. Western blot-based assessment of p-PI3K, PI13K, AKT, and p-AKT in MCF-7 cells after the overexpression of DLG3 (oe-DLG3 group) or after the overexpression of DLG3 + and the oe-DLG3+PI3K/AKT activator 740Y-P (oe-DLG3+740-Y-P group).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: Hypermethylation of DLG3 Promoter Upregulates RAC1 and Activates the PI3K/AKT Signaling Pathway to Promote Breast Cancer Progression 