Curcumin Protects against Renal Ischemia/Reperfusion Injury by Regulating Oxidative Stress and Inflammatory Response

Table 3

Effects of curcumin pretreatment on TNF-α, IL-6, and IL-8 mRNA levels in the kidney after renal ischemia-reperfusion injury.

Group	TNF-α (mRNA)	IL-6 (mRNA)	IL-8 (mRNA)
Sham group	1.07 ± 0.19^∗∗	1.14 ± 0.21^∗∗	0.96 ± 0.118^∗∗
RIRI group	12.36 ± 1.85	5.09 ± 0.37	7.63 ± 0.82
Low-dose curcumin group	6.53 ± 0.99^∗	2.07 ± 0.52^∗	3.77 ± 0.46^∗
Medium-dose curcumin group	5.87 ± 0.43^∗	1.76 ± 0.47^∗	2.49 ± 0.38^∗
High-dose curcumin group	4.74 ± 0.34^∗	1.48 ± 0.39^∗	2.01 ± 0.17^∗

^∗P < 0.05, ^∗∗P < 0.01, vs. the RIRI group.