Idebenone-Activating Autophagic Degradation of <i>α</i>-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach

<div>The effect of Idebenone on the AKT-mTOR pathway. (a) PI3K-AKT signaling pathway extracted from the KEGG analysis (ID: hsa04151). The potential targets and genes implicated in the pathway are shown in red. (b, c) Western blot images of the levels of p-AKT and AKT and and p-mTOR and mTOR, respectively.</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Idebenone-Activating Autophagic Degradation of <i>α</i>-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach 

Figure 7 | Idebenone-Activating Autophagic Degradation of α-Synuclein via Inhibition of AKT-mTOR Pathway in a SH-SY5Y-A53T Model of Parkinson’s Disease: A Network Pharmacological Approach 