Exploring the Molecular Mechanism of Astragali Radix-Curcumae Rhizoma against Gastric Intraepithelial Neoplasia by Network Pharmacology and Molecular Docking

Table 2

Topology attributes of 15 potential key targets and AUC of the ROC analysis.

Gene name	Protein name	Degree value	Betweenness centrality	Closeness centrality	AUC
EGFR	Epidermal growth factor receptor	15	0.4020073	0.5308642	0.254
AR	Androgen receptor	10	0.16157789	0.48314607	0.202
CYP3A4	Cytochrome P450 3A4	9	0.14518632	0.4673913	0.710
NR3C1	Glucocorticoid receptor	9	0.12596012	0.48314607	0.245
CYP1A1	Cytochrome P450 1A1	8	0.08766745	0.43	0.723
HMOX1	Heme oxygenase 1	7	0.11612398	0.37719298	0.733
DRD2	Dopamine receptor D2	6	0.04369106	0.38392857	0.755
DPP4	Dipeptidyl peptidase 4	6	0.11595851	0.38392857	0.859
ADRA2A	Alpha-2A adrenergic receptor	6	0.01645573	0.3495935	0.787
ADRA2C	Alpha-2C adrenergic receptor	6	0.01645573	0.3495935	0.754
NR1I2	Nuclear receptor subfamily 1 group I member 2	6	0.02101245	0.3495935	0.823
SLC6A2	Sodium-dependent noradrenaline transporter	6	0.13161388	0.36752137	0.215
LGALS4	Galectin-4	5	0.02235789	0.41346154	0.771
PTGER3	Prostaglandin E2 receptor EP3 subtype	5	0.03093548	0.37068966	0.185
PRKCB	Protein kinase C beta type	5	0.09021468	0.41346154	0.256

AUC: the area under the ROC curve.