EGCG Promotes Neurite Outgrowth through the Integrin β1/FAK/p38 Signaling Pathway after Subarachnoid Hemorrhage

Figure 3

The expression of pFAK and p-p38 after SAH in vivo. (a) EGCG downregulated the expression of pFAK (upper panel) (n = 3). SAH: 30 μL of OxyHb (150 μmol/L); EGCG: 50 mg/kg/d; p38 inhibitor: 200 μg/kg. Quantification of the expression of pFAK (lower panel). (b) EGCG inhibited p-p38 overexpression after SAH (upper panel) (n = 3) (bar, 50 μm), and quantification of the expression of p-p38 (lower panel). (A) control; (B) SAH (30 μL (150 μmol/L) of OxyHb); (C) EGCG (50 mg/kg/d); (D) FAK inhibitor (30 mg/kg). A representative trace of three repeats of each experiment is shown. vs. control and vs. SAH.

(a)

(b)