Evaluation of In Vivo Antidiarrheal Activity of Solvent Fractions of Hagenia abyssinica (Rosaceae) in Swiss Albino Mice
Table 2
Antidiarrheal effects of solvent fractions of H. abyssinica.
Group
Onset of diarrhea (min)
Number of wet feces
Number of total feces
% inhibition of defecation
Control
46.83 ± 3.21
9.10 ± 0.47
11.83 ± 0.60
—
CF 100 mg/kg
60.83 ± 2.12b
8.30 ± 0.34b
10.00 ± 0.72b
8.80
CF 200 mg/kg
72.83 ± 3.38b
7.60 ± 0.46b
8.60 ± 0.46b
16.50
CF 400 mg/kg
102 ± 2.47 ab
5.60 ± 0.23ab
7.20 ± 0.20ab
38.46
Loperamide 3 mg/kg
154.66 ± 6.8a
1.40 ± 0.2a
3.00 ± 0.25a
84.60
Control
44 ± 2.84
9.10 ± 0.47
10.00 ± 0.85
—
EAF 100 mg/kg
55.5 ± 2.64b
8.16 ± 0.77b
9.00 ± 0.85b
10.32
EAF 200 mg/kg
68.00 ± 3.65b
7.10 ± 0.83b
7.00 ± 0.77b
22.20
EAF 400 mg/kg
99.00 ± 4.15ab
3.83 ± 0.34ab
5.33 ± 0.49ab
57.91
Loperamide 3 mg/kg
141.00 ± 7.14a
1.66 ± 0.21a
3.10 ± 0.32a
76.62
Control
48.50 ± 4.52
9.10 ± 0.47
10.16 ± 0.75
—
AF 100 mg/kg
71.33 ± 8.76b
5.16 ± 0.47b
6.33 ± 0.71b
43.29
AF 200 mg/kg
88.65 ± 7.74ab
3.50 ± 0.42ab
5.50 ± 0.61a
61.53
AF 400 mg/kg
91.57 ± 10.88ab
2.00 ± 0.25a
3.66 ± 0.33a
78.00
Loperamide 3 mg/kg
138.50 ± 7.65a
1.83 ± 0.33a
3.60 ± 0.18a
80.00
Data are expressed as mean ± SEM (n = 6); analysis was performed with One-Way ANOVA followed by Tukey test; acompared to negative control; bcompared to loperamide 3 mg/kg; ,, and ; CF: chloroform fraction; EAF: ethyl acetate fraction; AF: aqueous fraction; negative controls received 10 ml/kg distilled water.
