Evaluation of In Vivo Antidiarrheal Activity of Solvent Fractions of Hagenia abyssinica (Rosaceae) in Swiss Albino Mice

Table 3

Effects of solvent fractions on castor oil-induced gastrointestinal motility in mice.

Dose administered	Length of small intestine (cm)	Distance moved by the charcoal meal (cm)	Peristaltic index (%)	% inhibition
Control	58.30 ± 1.02	46.50 ± 1.14	84.82 ± 1.47	—
CF 100 mg/kg	58.16 ± 1.24	46.83 ± 1.44^b	80.53 ± 1.67^b	7.10
CF 200 mg/kg	57.16 ± 1.93	40.83 ± 2.41^b	71.43 ± 3.14^a^b	17.61
CF 400 mg/kg	56.83 ± 0.94	33.83 ± 1.86^a^b	59.50 ± 3.92^a^b	31.70
EA 100 mg/kg	55.33 ± 1.49	41.00 ± 3.04^b	74.50 ± 4.72^a^b	14.00
EA 200 mg/kg	55.83 ± 1.04	31 ± 2.61^b	55.54 ± 4.24^a^b	35.90
EA 400 mg/kg	56.38 ± 1.62	23.50 ± 1.47^a^b	41.68 ± 2.57^a^b	51.92
AF 100 mg/kg	56.60 ± 1.23	34.16 ± 1.66^b	60.35 ± 3.56^b	30.41
AF 200 mg/kg	56.16 ± 0.96	25.66 ± 2.57^a^b	45.69 ± 4.22^a^b	47.34
AF 400 mg/kg	57.00 ± 1.45	20.33 ± 1.23^a^b	35.66 ± 3.37^a^b	58.83
Loperamide 3 mg/kg	55.83 ± 0.87	18.66 ± 0.88^a	33.00 ± 1.52^a	59.80

Data are expressed as mean ± SEM (n = 6); analysis was performed with One-Way ANOVA followed by Tukey test; ^acompared to negative control; ^bcompared to loperamide 3 mg/kg; , , and ; CF: chloroform fraction; EAF: ethyl acetate fraction; AF: aqueous fraction; negative controls received 10 ml/kg distilled water.