Evaluation of In Vivo Antidiarrheal Activity of Solvent Fractions of Hagenia abyssinica (Rosaceae) in Swiss Albino Mice

Table 4

Effects of solvent fractions on castor oil-induced enteropooling in mice.

Dose administered	Mean volume of small intestinal content (gm)	% inhibition	Mean weight of small intestinal content (ml)	% inhibition
Control	0.76 ± 0.04	—	0.81 ± 0.01	—
CF 100 mg/kg	0.69 ± 0.02^b	9.20	0.69 ± 0.018^a^b	14.80
CF 200 mg/kg	0.58 ± 0.02^a^b	23.60	0.6 ± 0.02^a^b	26.00
CF 400 mg/kg	0.40 ± 0.04^a	47.30	0.48 ± 0.02^a	40.70
EA 100 mg/kg	0.62 ± 0.21^a^b	18.40	0.6 ± 0.02^a^b	26.00
EA 200 mg/kg	0.53 ± 0.09^a^b	30.20	0.51 ± 0.02^a^b	37.00
EA 400 mg/kg	0.36 ± 0.14^a	52.60	0.38 ± 0.01^a	53.00
AF 100 mg/kg	0.68 ± 0.018^b	10.50	0.71 ± 0.01^a^b	12.30
AF 200 mg/kg	0.55 ± 0.02^a^b	27.60	0.59 ± 0.01^a^b	27.10
AF 400 mg/kg	0.45 ± 0.08^a	40.70	0.43 ± 0.02^a	47.00
Loperamide 3 mg/kg	0.36 ± 0.02^a	52.60	0.4 ± 0.01^a	50.60

Data are expressed as mean ± SEM (n = 6); analysis was performed with One-Way ANOVA followed by Tukey test; ^acompared to negative control; ^bcompared to loperamide 3 mg/kg; , , and ; CF, chloroform fraction; EAF: ethyl acetate fraction; AF: aqueous fraction; negative controls received 10 ml/kg distilled water.