Evaluation of In Vivo Antidiarrheal Activity of Solvent Fractions of Hagenia abyssinica (Rosaceae) in Swiss Albino Mice

Table 5

In vivo antidiarrheal index of solvent fractions of H.abyssinica leaves.

Dose	Delay in defecation (time of onset in min, Dfreq) (%)	Gut meal travel distance (Gmeq) (%)	Purging frequency in a number of wet stools (%)	In vivo ADI
DW 10 ml/kg	—	—	—	—
CF 100 mg/kg	29.89	7.10	8.80	12.31
CF 200 mg/kg	55.51	17.61	16.5	25.26
CF 400 mg/kg	117.80	31.7	38.46	52.37
EAF 100 mg/kg	26.13	14.00	10.32	15.57
EAF 200 mg/kg	54.54	35.90	22.2	35.16
EAF 400 mg/kg	125.00	51.92	57.91	72.17
AF 100 mg/kg	47.07	30.40	43.29	39.54
AF 200 mg/kg	82.78	47.30	61.53	62.22
AF 400 mg/kg	88.80	58.83	78.00	74.14
Loperamide 3 mg/kg	185.56	59.80	82.57	97.13

DW = distilled water, CF = chloroform fraction, EAF = ethyl acetate fraction, AF = aqueous fraction, and ADI = antidiarrheal index.