Antimalarial Effect of the Root of Silene macrosolen A. Rich (Caryophyllaceae) on Plasmodium-berghei-Infected Mice

Table 3

Effect of the crude extract and solvent fractions of S. macrosolen on the parasite level, parasite suppression, and MST of P. berghei-infected mice in the 4-day suppressive test.

Group	Doses (mg/kg)	% parasitemia (M ± SEM)	% suppression	Mean survival time (days)
DW	10 ml/kg	54.82 ± 2.97	0	7.17 ± 0.31
CQ	25	0.00 ± 0.00^a3	100^a3	30.00 ± 0.00^a3
SM	100	46.97 ± 0.97^b3e2	14.33^b3e2	7.67 ± 0.21
SM	200	42.78 ± 2.44^a2b3e1	21.97^a2b3e1	8.33 ± 0.33^a1
SM	400	33.32 ± 2.08^a3b3c2d1	39.23^a3b3c2d1	8.67 ± 0.33^a2
AF	100	38.48 ± 5.66^a1b3	29.81^a1b3	8.33 ± 0.33^b3
AF	200	32.63 ± 3.23^a2b3	40.48^a2b3	9.00 ± 0.37^a2b3
AF	400	31.21 ± 4.02^a2b3	43.07^a2b3	9.33 ± 0.42^a2b3
TE	10 ml/kg	48.85 ± 7.34	0	6.67 ± 0.33
CQ	25	0.29 ± 0.12^a3	99.41^a3	30.00 ± 0.00^a3
CF	100	41.79 ± 3.91^b3	14.46^b3	8.00 ± 0.52^b3
CF	200	39.71 ± 4.10^b3	18.72^b3	8.17 ± 0.40^b3
CF	400	30.10 ± 3.90^a1b2	38.38^a1b2	8.50 ± 0.34^a1b3
EF	100	35.20 ± 3.19^b3	27.95^b3	8.50 ± 0.34^a1b3
EF	200	29.46 ± 3.72^a1b2	39.70^a1b2	8.67 ± 0.42^a2b3
EF	400	28.03 ± 4.61^a1b2	42.61^a1b2	9.00 ± 0.52^a2b3

Data are expressed as mean ± SEM (n = 6); AF = aqueous fraction; CQ = chloroquine; DW = distilled water (negative control for the crude extract and AF fraction); TE = 2% Tween 80 (negative control for CF and EF fractions); CF = chloroform fraction; EF = ethyl acetate fraction; a = compared to the negative control; b = compared to the positive control; c = compared to 100 mg/kg crude extract; d = compared to 200 mg/kg crude extract; e = compared to 400 mg/kg crude extract; SM = Silene macrosolen; 1 = ; 2 = ; 3 = .