Evidence-Based Complementary and Alternative Medicine

Research Article

Antimalarial Effect of the Root of Silene macrosolen A. Rich (Caryophyllaceae) on Plasmodium-berghei-Infected Mice

Table 4

Effect of the crude extract and solvent fractions of S. macrosolen on body weight and rectal temperature of P. berghei-infected mice in the 4-day suppressive test.


Groups	Weight (g)			Temperature
Groups	D0	D4	% change	D0	D4	% change

DW10 ml/kg	29.17 ± 0.60	24.73 ± 0.74	−15.2	36.35 ± 0.18	33.67 ± 0.37	−7.38
CQ 25	27.85 ± 0.85	28.25 ± 0.79	1.50^a3	36.15 ± 0.08	36.07 ± 0.15	−0.23^a3
SM100	28.67 ± 0.85	25.48 ± 0.72	−11.05^b3	36.23 ± 0.22	33.73 ± 0.37	−6.90^b3
SM200	29.45 ± 0.79	27.42 ± 0.68	−6.86^a3b3	36.35 ± 0.09	34.87 ± 0.15	−4.07^a1b2
SM400	29.33 ± 0.61	27.08 ± 0.72	−7.72^a3b3	35.75 ± 0.31	34.88 ± 0.31	−2.42^a3
AF100	28.13 ± 0.79	24.82 ± 0.72	−11.79^b2d1	36.70 ± 0.35	34.98 ± 0.39	−4.67^b1
AF200	27.00 ± 0.57	24.93 ± 0.65	−7.68^a2b2c1	36.82 ± 0.46	35.68 ± 0.47	−3.08^a1
AF400	27.68 ± 0.52	25.10 ± 0.54	−9.34^a2b2	36.67 ± 0.20	35.12 ± 0.51	−4.21^b1

TE10 ml/kg	27.60 ± 0.68	24.90 ± 0.68	−9.78	36.55 ± 0.13	34.45 ± 0.40	−5.75
CQ25	26.58 ± 0.45	28.33 ± 0.43	6.55^a3	36.25 ± 0.21	36.40 ± 0.17	0.41^a3
CF100	27.40 ± 0.77	25.27 ± 0.93	−7.79^b3d1	36.47 ± 0.27	35.02 ± 0.15	−3.98^b1
CF200	27.40 ± 0.77	26.20 ± 0.83	−4.38^a1b3	36.63 ± 0.25	35.12 ± 0.29	−4.14^b2
CF400	26.90 ± 0.55	26.18 ± 0.56	−2.65^a3b3c1	36.83 ± 0.21	35.75 ± 0.40	−2.94
EF 100	27.12 ± 0.75	25.65 ± 0.94	−5.50^b3	36.70 ± 0.31	35.15 ± 0.33	−4.22^b2
EF200	27.20 ± 0.68	26.52 ± 0.94	−2.59^a2b3	36.53 ± 0.33	35.97 ± 0.33	−1.55^a2
EF400	27.73 ± 0.79	26.40 ± 0.73	−4.77^a1b3	36.70 ± 0.19	36.17 ± 0.12	−1.45^a2

Data are expressed as mean ± SEM (n = 6); CQ = chloroquine; DW = distilled water(negative control for the crude and AF fraction); SM= Silene macrosolen; D0 = day 0; D4 = day 4; a = compared to the negative control; b = compared to the positive control; c = compared to 100 mg/kg of CF; d = compared to 400 mg/kg of CF; AF = aqueous fraction; TE = 2% Tween 80 (negative control for CF and EF fractions); CF = chloroform fraction; EF = ethyl acetate fraction; 1 = ; 2 = ; 3 = .