Antimalarial Effect of the Root of Silene macrosolen A. Rich (Caryophyllaceae) on Plasmodium-berghei-Infected Mice

Table 5

Effect of the crude extract of S. macrosolen on the parasite level, parasite suppression, and mean survival time of P. berghei-infected mice in the prophylactic test.

Group	Doses (mg/kg)	% parasitemia (M ± SEM)	% suppression	Mean survival time (days)
DW	10 ml/kg	55.71 ± 1.14	0	6.67 ± 0.33
CQ	25	0.38 ± 0.14^a2	99.32^a2	29.17 ± 0.83^a2
SM	100	48.75 ± 4.89^b2	12.48^b2	7.33 ± 0.21^b2
SM	200	43.88 ± 5.59^b2	21.23^b2	7.50 ± 0.22^b2
SM	400	38.43 ± 3.93^a1b2	31.02^a1b2	8.33 ± 0.21^b2

Data are expressed as mean ± SEM (n = 6); CQ = chloroquine; DW = distilled water; SM = Silene macrosolen; a = compared to the negative control; b = compared to the positive control 1 = ; 2 = .