Antimalarial Effect of the Root of Silene macrosolen A. Rich (Caryophyllaceae) on Plasmodium-berghei-Infected Mice

Table 7

Effect of the crude extract of S. macrosolen on the parasite level, parasite suppression, and mean survival time of P. berghei-infected mice in Rane’s test.

Group	Dose (mg/kg)	% parasitemia (mean ± SEM)		% suppression	Mean survival time (days)
		D3	D7
DW	10 ml/kg	49.89 ± 1.84	56.65 ± 3.19	0	6.17 ± 0.31
CQ	25	48.59 ± 2.25	0.03 ± 0.01^a3	99.95^a3	30.00 ± 0.00^a3
SM	100	50.43 ± 3.29	45.20 ± 2.75^a2b3d1	20.23^a2b3	6.83 ± 0.31^b3
SM	200	47.07 ± 1.49	43.41 ± 1.17^a2b3	23.38^a2b3	7.50 ± 0.22^a2b3
SM	400	47.83 ± 0.99	36.36 ± 1.7^a3b3c1	35.82^a3b3c1	7.67 ± 0.21^a2b3

Data are expressed as mean ± SEM (n = 6); CQ = chloroquine; DW = distilled water; D3 = day 3; D7 = day7; SM = Silene macrosolen; a = compared to the negative control; b = compared to the positive control; c = compared to 100 mg/kg crude extract; d = compared to 400 mg/kg crude extract; 1 = ; 2 = ; 3 = .