Antimalarial Effect of the Root of Silene macrosolen A. Rich (Caryophyllaceae) on Plasmodium-berghei-Infected Mice

Table 8

Effect of the crude extract of S. macrosolen on body weight and rectal temperature of P. berghei-infected mice in Rane’s test.

Groups	Weight (g)			Temperature
	D4	D7	% changes	D4	D7	% changes
DW10 ml/kg	27.75 ± 0.31	24.15 ± 0.35	−12.98	35.48 ± 0.26	32.93 ± 0.21	−7.15
CQ25	27.17 ± 0.54	26.40 ± 0.60	−2.77^a3	35.40 ± 0.19	34.75 ± 0.21	−1.84^a2
SM100	27.83 ± 0.54	25.28 ± 0.48	−9.15^b1	35.02 ± 0.26	33.52 ± 0.33	−4.26
SM200	27.12 ± 0.59	25.15 ± 0.71	−7.27^a1	35.25 ± 0.18	34.10 ± 0.16	−3.26^a1
SM400	26.77 ± 0.82	24.73 ± 0.91	−7.66^a1	35.25 ± 0.19	34.28 ± 0.29	−2.73^a1

Data are expressed as mean ± SEM (n = 6); CQ = chloroquine; DW = distilled water; SM = Silene macrosolen; D3 = day 3; D7 = day 7; a = compared to the negative control; b = compared to the positive control; 1 = ; 2 = ; 3 = .