Nephroprotective Effects of Zataria multiflora Boiss. Hydroalcoholic Extract, Carvacrol, and Thymol on Kidney Toxicity Induced by Cisplatin in Rats

Table 2

Effects of Z.M.B hydroalcoholic extract, carvacrol, and thymol on kidney markers in Cis-induced toxicity in rats.

Treatment group	BUN (mg/dL)	Creatinine (mg/dL)	Body weight/kidney weight index
Control	17.40 ± 0.78	0.48 ± 0.02	0.74 ± 0.05
Cis	29.32 ± 2.76	0.61 ± 0.03	1.03 ± 0.03
Z.M.B only	18.68 ± 1.34	0.49 ± 0.02	0.73 ± 0.04
Z.M.B + Cis	22.52 ± 2.26	0.53 ± 0.04	0.84 ± 0.03^#
Carvacrol + Cis	20.95 ± 1.89^#	0.5 ± 0.02	0.89 ± 0.04^#
Thymol + Cis	20.88 ± 0.95^#	0.57 ± 0.03	0.80 ± 0.03^##

Values are presented as mean ± SEM. Statistically significant compared with the control group,  ≤ 0.05 and  ≤ 0.001; statistically significant compared with the Cis group, ^# ≤ 0.05 and ^## ≤ 0.01. Cis: cisplatin; Z.M.B: hydroalcoholic extract of Zataria multiflora Boiss.