Nephroprotective Effects of Zataria multiflora Boiss. Hydroalcoholic Extract, Carvacrol, and Thymol on Kidney Toxicity Induced by Cisplatin in Rats

Table 3

Effects of Z.M.B hydroalcoholic extract, carvacrol, and thymol on the serum oxidative stress markers in Cis-induced toxicity in rats.

Treatment group	MDA (nmol/L)	NO (µmol/L)	FRAP (µmol/L)
Control	487.17 ± 12.21	0.50 ± 0.02	305.10 ± 34.07
Cis	612.17 ± 16.11	1.20 ± 0.12	672.43 ± 74.73
Z.M.B only	554.82 ± 14.91	0.50 ± 0.04	361.87 ± 47.77
Z.M.B + Cis	443.38 ± 52.17^##	0.59 ± 0.09^##	492.75 ± 72.29
Carvacrol + Cis	419.87 ± 29.92^###	0.48 ± 0.05^###	566.68 ± 143.76
Thymol + Cis	449.59 ± 11.43^#	0.57 ± 0.04^##	610.35 ± 62.38

Values are presented as mean ± SEM. Statistically significant compared with the control group,  ≤ 0.05 and  ≤ 0.001; statistically significant compared with the Cis group, ^# ≤ 0.05, ^## ≤ 0.01, and ^### ≤ 0.001. Cis: cisplatin; Z.M.B: hydroalcoholic extract of Zataria multiflora Boiss.