Nephroprotective Effects of Zataria multiflora Boiss. Hydroalcoholic Extract, Carvacrol, and Thymol on Kidney Toxicity Induced by Cisplatin in Rats

Table 4

Effects of Z.M.B hydroalcoholic extract, carvacrol, and thymol on the kidney tissue oxidative stress markers in Cis-induced toxicity in rats.

Treatment group	MDA (nmol/g tissue)	NO (µmol/g tissue)	tSH (µmol/g tissue)
Control	71.64 ± 0.91	0.35 ± 0.06	17.30 ± 1.68
Cis	84 ± 1.33	0.64 ± 0.02	10.03 ± 0.24
Z.M.B only	77.88 ± 3.20	0.31 ± 0.04	13.36 ± 0.95
Z.M.B + Cis	76.28 ± 1.98	0.34 ± 0.03^###	11.28 ± 0.62
Carvacrol + Cis	72.97 ± 0.94^#	0.39 ± 0.03^##	9.85 ± 0.97
Thymol + Cis	72.97 ± 2.81^#	0.37 ± 0.03^###	12.20 ± 1.53

Values are presented as mean ± SEM. Statistically significant compared with the control group,  ≤ 0.05 and  ≤ 0.001; statistically significant compared with the Cis group, ^# ≤ 0.05, ^## ≤ 0.01, and ^### ≤ 0.001. Cis: cisplatin; Z.M.B: hydroalcoholic extract of Zataria multiflora Boiss.