Effects of Various Preextraction Treatments of Crinum asiaticum Leaf on Its Anti-Inflammatory Activity and Chemical Properties

Table 1

Yields (%w/w), anti‐inflammatory activity by the inhibitory effect on three pathways in RAW 264.7 cells, and %total phenolic content of the ethanolic extracts from different preextraction treatments of C. asiaticum.

Sample	%yields	Anti-inflammatory activity by inhibitory effect on three pathways in RAW 264.7 cells (IC50 ± SEM) (μg/mL)			%Total phenolic content (mg GAE/g)
		NO	TNF-α	PGE2
CAA	22.88	16.66 ± 1.42	25.21 ± 1.11	>100	23.20 ± 1.36
CAM	24.23	20.42 ± 0.57	37.60 ± 0.58^∗	>100	14.53 ± 0.63
CAG	25.75	21.35 ± 0.56^∗	46.36 ± 0.48^∗	>100	13.10 ± 1.02
CAC	21.53	22.48 ± 1.09^∗	45.63 ± 1.54^∗	>100	12.01 ± 0.84
Prednisolone	—	1.05 ± 0.13	0.07 ± 0.00	0.07 ± 0.00	—
Diclofenac	—	>100	>100	0.004 ± 0.001	—
Lycorine	—	0.40 ± 0.00	>0.8	>0.8^(t)	—

^∗Significant difference (p < 0.05) compared with CAA analyzed by Tukey’s multiple comparison test. _(t)Cytotoxicity was observed at a higher concentration.