Derrone Inhibits Platelet Aggregation, Granule Secretion, Thromboxane A₂ Generation, and Clot Retraction: An In Vitro Study

Figure 2

Inhibitory action of derrone on platelet aggregation, cytotoxicity, and half maximal inhibitory concentration. (a) Inhibitory action of derrone on collagen-induced human platelet aggregation. (b) Inhibitory action of derrone on thrombin-induced human platelet aggregation. (c) Inhibitory action of derrone on U46619-induced human platelet aggregation. (d) Action of derrone on cytotoxicity. (e) Half maximal inhibitory concentration (IC₅₀) value of derrone in collagen-induced human platelet aggregation. Platelet aggregation and cytotoxicity were carried out as described in the Materials and Methods section. Data are expressed as mean ± standard deviation (n = 4). and versus each agonist-stimulated human platelets. NS, not significant.

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