Derrone Inhibits Platelet Aggregation, Granule Secretion, Thromboxane A₂ Generation, and Clot Retraction: An In Vitro Study

Figure 3

Inhibitory action of derrone on [Ca²⁺]_i mobilization, IP₃RI phosphorylation, serotonin release, and ERK phosphorylation. (a) Inhibitory action of derrone on collagen-induced [Ca²⁺]_i mobilization (b) inhibitory action of derrone on collagen-induced IP₃RI (Ser¹⁷⁵⁶) phosphorylation. (c) Inhibitory action of derrone on collagen-induced serotonin release. (d) Inhibitory action of derrone on collagen-induced ERK 1/2 phosphorylation. Measurement of [Ca²⁺]_i mobilization and serotonin release and western blotting were performed as described in the Materials and Methods section. Data are expressed as mean ± standard deviation (n = 4). and versus the collagen-stimulated human platelets.

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