Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia
Table 2
The effect of NCNL on serum biochemical parameters in rats with postpartum hypogalactia.
Normal
Control
CNL
NCNLL
NCNLH
GH (ng/mL)
20.61 ± 1.97
17.51 ± 0.63
16.69 ± 1.44
15.48 ± 1.62
16.37 ± 1.07
PRL (ng/L)
160.33 ± 10.43
121.61 ± 2.61
130.33 ± 13.01
155.38 ± 9.28
134.26 ± 8.55
DA (ng/L)
16.42 ± 0.63
13.31 ± 1.43
16.84 ± 2.06
15.52 ± 0.45
16.08 ± 1.64
T3 (ng/mL)
9.49 ± 0.54
7.95 ± 0.24
9.33 ± 0.74
9.01 ± 0.53
7.99 ± 0.41
T4 (ng/mL)
214.02 ± 23.76
142.10 ± 15.51
209.25 ± 20.49
190.14 ± 10.35
177.81 ± 18.17
E2 (pg/mL)
175.35 ± 17.14
226.23 ± 13.16
197.40 ± 6.85
199.81 ± 6.32
187.74 ± 2.39
PROG (ng/mL)
12.98 ± 0.28
14.45 ± 0.25
13.18 ± 0.31
13.84 ± 0.03
14.18 ± 0.24
Ca (pg/mL)
2.09 ± 0.08
2.46 ± 0.13
2.15 ± 0.11
1.89 ± 0.14
2.07 ± 0.11
UREA (U/L)
7.66 ± 0.77
9.30 ± 0.89
7.15 ± 0.37
6.76 ± 0.69
7.91 ± 1.05
INS (mU/L)
45.19 ± 3.32
37.69 ± 1.99
38.94 ± 5.42
47.89 ± 4.24
39.76 ± 3.11
IGF-1 (ng/mL)
26.98 ± 0.26
23.76 ± 0.84
26.24 ± 1.45
27.62 ± 2.84
24.75 ± 2.92
GLU (mg/dL)
7.62 ± 0.98
10.45 ± 1.25
8.31 ± 0.60
6.60 ± 1.02
7.09 ± 0.80
ALT (U/L)
26.00 ± 3.16
32.00 ± 3.58
18.50 ± 1.66
12.50 ± 0.87
15.50 ± 1.66
AST (U/L)
148.00 ± 21.23
195.25 ± 14.31
144.00 ± 9.09
122.00 ± 14.24
144.67 ± 7.36
TCHO (mmol/L)
1.56 ± 0.11
1.95 ± 0.28
1.69 ± 0.14
1.68 ± 0.14
1.51 ± 0.17
TG (mmol/L)
0.53 ± 0.10
0.83 ± 0.09
0.66 ± 0.07
0.60 ± 0.09
0.42 ± 0.02
The data are expressed as the mean ± SD (n = 7); versus the normal group; versus the control group. Normal: normal group. Control: bromocriptine-induced hypogalactia control group. CNL: traditional Cui Nai Ling aqueous extract 1000 mg/kg administered group. NCNLL: new Cui Nai Ling aqueous extract 500 mg/kg administered group. NCNLH: new Cui Nai Ling aqueous extract 1000 mg/kg administered group.
