Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice
Table 4
Effect of dietary supplementation with EtSF-S or FF on the hepatic, fat, and renal mass/index in ND- and HFFD-fed mice.
Groups
Dose (%, w/w)
A : liver
B : fat
C : kidney
Mass (g)
Index-1
Mass (g)
Index-1
Index-2
Mass (g)
Index-1
Index-2
ND-fed mice
ND
-
1.26 ± 0.15
4.24 ± 0.36
0.50 ± 0.12
1.68 ± 0.42
1.76 ± 0.44
0.32 ± 0.04
1.09 ± 0.10
1.14 ± 0.10
ND/EtSF-S
10
1.36 ± 0.28
4.40 ± 0.65
0.32 ± 0.14
1.00 ± 0.46
1.09 ± 0.50
0.33 ± 0.05
1.07 ± 0.11
1.16 ± 0.12
ND/FF
0.03
1.82 ± 0.22
6.11 ± 0.60
0.28 ± 0.10
0.94 ± 0.34
1.00 ± 0.36
0.36 ± 0.03
1.19 ± 0.08
1.27 ± 0.09
HFFD-fed mice
ND
—
1.53 ± 0.26
4.29 ± 0.38
0.48 ± 0.28
1.37 ± 0.66
1.47 ± 0.71
0.38 ± 0.05
1.06 ± 0.06
1.14 ± 0.06
HFFD
—
1.56 ± 0.18
4.25 ± 0.42
0.56 ± 0.26
1.63 ± 0.74
1.70 ± 0.77
0.36 ± 0.04
1.00 ± 0.08
1.04 ± 0.08
HFFD/EtSF-S
1
1.50 ± 0.19
4.25 ± 0.36
0.68 ± 0.31
1.98 ± 0.83
2.08 ± 0.87
0.35 ± 0.05
0.99 ± 0.13
1.04 ± 0.14
5
1.79 ± 0.22†
5.13 ± 0.43††
0.58 ± 0.21
1.71 ± 0.60
1.80 ± 0.63
0.34 ± 0.04
0.97 ± 0.09
1.03 ± 0.10
10
1.99 ± 0.14††
5.87 ± 0..32††
0.66 ± 0.14
1.97 ± 0.41
2.10 ± 0.44
0.32 ± 0.04†
0.94 ± 0.11
1.00 ± 0.12
HFFD/FF
0.03
2.02 ± 0.31††
5.46 ± 0.52††
0.63 ± 0.33
1.78 ± 0.86
1.93 ± 0.93
0.45 ± 0.07††
1.21 ± 0.14†
1.31 ± 0.15†
Mice were fed with normal diet (ND) or high fructose/fat diet (HFFD) for 3 months. Then, animals were fed with ND or HFFD without and with supplementation with the ethanol extract of Schisandrae Fructus (SF) seed (EtSF-S) or fenofibrate (FF). After 30 days of experiment, hepatic, fat (collected from uterine surface), or renal weight and index-1 (hepatic, fat, or renal weight/body weight × 100) and index-2 (fat or renal weight/body weight-hepatic weight × 100) were then measured. The concentrations of EStF-S in chow diet were estimated on the basis of crud herbal material (SF seed). Values given are the mean ± SD, with N = 10. , vs. ND alone; †,†† vs. HFFD alone.
