Artemisinin-Based Combination Therapy Synergized with Medicinal Plants to Induce Musculotoxic Effects

Table 1

Effect of monotherapies on myocyte mortality.

Products	Days of incubation (D)	Mean ± SD
		0	1	2	3	4	5
MEM 2%	0.3	0.1	0.1	0.5	0.2	0.3	0.24 ± 0.17
ASAQ	0.3	34	67.97	76.98	81.96	51.16	62.41 ± 19.74
AL	0.3	11.74	16.70	28.70	28.60	12.76	19.70 ± 8.38
PSA	0.3	8.78	20.58	17.40	58.35	53.19	31.66 ± 22.50
PEP	0.3	18.06	5.99	5.39	0	13.88	8.66 ± 7.22

ASAQ: artesunate/amodiaquine; AL:artemether/lumefantine; PSA:plant of Sida acuta; PEP: plant of Enantia polycarpa; SD = standard deviation; Statistical analyses were assessed using one-way analysis of variance (ANOVA) followed by Bonferroni’s posttest  < 0,05 versus control.