Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis

Figure 6

Schematic mechanism of Mox ameliorates POF through inhibiting NLRP3-/caspase-1-/GSDMD-dependent pyroptosis. Mox directly inhibited TXNIP/NLRP3/caspase-1 signaling-induced pyroptosis. Meanwhile, Mox indirectly decreased NLRP3, pro-IL-1β, and pro-IL-18 through inhibiting TLR4/MyD88/NF-κB signaling. Our results show that inhibiting pyroptosis or giving Mox might be a new treatment for POF.