The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke

Figure 5

The effect of PNS on expression of RIG-signaling pathway and inflammatory cell infiltration in MCAO rats. (a) The expression of RIG-I, Traf2, NF-κB (p65) were detected in vascular endothelium of MCAO rats by immunohistochemical experiment (magnification, ×1000). The levels of TNF-α (b) and IL-8 (c) were measured by ELISA. (d) Showed the gating strategy for myeloid cells using the surface markers CD45, CD11b and Ly6G by flow cytometry. Bar graph (e) showed the percentage of myeloid cells subsets. ^## < 0.01, ^### < 0.001 versus sham group;  < 0.05 versus model group.

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