Tetragonia tetragonioides Relieves Depressive-Like Behavior through the Restoration of Glial Loss in the Prefrontal Cortex

Figure 1

Experimental schedule. 50 mice were randomly divided into five groups (n = 10 for each group): control (sham surgery + distilled water), negative control (L-AAA injection + distilled water), positive control (L-AAA injection + imipramine 15 mg/kg), low-dose (L-AAA injection + TTK 100 mg/kg), and high dose (L-AAA injection + TTK 300 mg/kg). After 2 weeks of administration of drugs or distilled water, cannula implantation and infusion of L-AAA were performed. Subsequently, behavior tests including the open field test (OFT), tail suspension test (TST), forced swimming test (FST), and sucrose preference test (SPT) were carried out.