Synergistic Herb-Herb Interaction of the Antinociceptive and Anti-Inflammatory Effects of Syzygium aromaticum and Rosmarinus officinalis Combination

Figure 2

(a, b) Temporal courses of inflammation (%) induced by intraplantar injection of 50 μL 1% carrageenan in the right paw of the rats. Carrageenan-induced edema was measured each hour for 6 hours in the presence of R. officinalis (a), S. aromaticum (b), or vehicle (control group). All treatments were intraplantar injected in the right paw of the rats 15 minutes before carrageenan. Each point represents the average of 6 animals tested ± SEM. (c) AUCs obtained from temporal courses of % inflammation in the presence of R. officinalis, S. aromaticum, or Veh. Each bar represents the mean AUC of 6 animals ± SEM. Significant difference from the vehicle group () as determined by a one-way ANOVA followed by Dunnett’s test.

(a)

(b)

(c)