Evidence-Based Complementary and Alternative Medicine / 2021 / Article / Tab 7 / Research Article
Evaluation of the Modulatory Effect of Annona muricata Extracts on the Activity of Some Selected Antibiotics against Biofilm-Forming MRSA Table 7 Modulatory activity of extracts of various parts of A. muricata on some selected antibiotics against MRSA.
Organisms MICs µg/mL of antibiotics + aqueous/ethanolic extracts of Annona muricata (0.5 µ g/mL) against MRSA Aqueous extracts Ampicillin Root Stem Leaf Seed Peel A B MF/IMA A B MF/IMA A B MF/IMA A B MF/IMA A B MF/IMA Methicillin-resistant Staphylococcus aureus (NCTC 12493) 32.0 64.0 0.5 (−) 32.0 64.0 0.5 (−) 32.0 32.0 1.0 (=) 32.0 64.0 0.5 (−) 32.0 64.0 0.5 (−) Tetracycline 32.0 8.0 4.0 (+) 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) Streptomycin 64.0 2.0 32.0 (+) 64.0 4.0 16.0 (+) 64.0 4.0 16.0 (+) 64.0 16.0 4.0 (+) 64.0 8.0 8.0 (+) Ethanolic extracts Ampicillin 64.0 32.0 2.0 (+) 64.0 64.0 1.0 (=) 64.0 8.0 8.0 (+) 64.0 64.0 1.0 (=) 64.0 16.0 4.0 (+) Tetracycline 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) 32.0 16.0 2.0 (+) 32.0 8.0 4.0 (+) Streptomycin 64.0 16.0 4.0 (+) 64.0 8.0 8.0 (+) 64.0 4.0 16 (+) 64.0 64.0 1.0 (=) 64.0 8.0 8.0 (+)
IMA = interpretation of modulatory activity; MF = modulatory factor; (−) = antagonism; (+) = potentiation; (=) = intermediate; subinhibitory concentration of extract: 0.5 mg/mL, A: MIC of antibiotic alone (μ g/mL); B: MIC of antibiotics in the presence of subinhibitory concentration of the extract (μ g/mL).
