Antidiarrheal Effect of 80% Methanol Extract and Fractions of Clerodendrum myricoides (Hochst.) Vatke (Lamiaceae) Leaf in Swiss Albino Mice

Table 4

In vivo antidiarrheal index of 80% MeOH and solvent fractions of C. myricoides leaf.

Treatment (mg/kg)	Delay in diarrhea (minute)	Gut meal travel distance (Gmeq) (%)	Purging frequency (Pfreq) (%)	Antidiarrheal index (ADI)
MeOH 100	37.75	42.57	47.33	42.37
MeOH 200	83.92	55.29	54.53	63.25
MeOH 400	128.21	63.55	69.14	82.59
PC	152.24	67.27	72.74	90.65
HF 100	7.49	16.73	14.61	12.23
HF 200	18.42	24.72	21.81	21.23
HF 400	61.15	32.97	45.47	45.09
CF 100	26.84	38.88	43.62	35.71
CF 200	77.05	53.24	50.92	59.33
CF 400	123.53	59.88	65.43	78.51
AF 100	24.85	32.26	30.52	29.03
AF 200	73.13	42.16	52.49	54.50
AF 400	126.30	58.00	62.67	77.14
PC	169.04	64.82	72.84	92.7 6

Values are expressed as mean ± standard error of mean (n = 6). MeOH: 80% methanol extract; HF: hexane fraction; CF: chloroform fraction; AF: aqueous fraction; PC: positive control (atropine 1 mg/kg and loperamide 3 mg/kg); Dfreq: delay in diarrhea onset (in % of control). Gmeq is the intestinal meal travel reduction (in % of control). Pfreq is the purging frequency as the number of wet feces’ reduction (in % of control).