Aconitine Induces TRPV2-Mediated Ca²⁺ Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis

Figure 1

Influence of aconitine on apoptosis and Ca²⁺ influx of cardiomyocytes. (a, b) The rate of cell apoptosis was measured by flow cytometry. (c, d) The expressions of apoptosis-related proteins, Bcl-2, Bax, and cleaved caspase-3, were detected by western blotting. (e) The level of Ca²⁺ influx in each group was shown by the normalized ratio of 340/380. NC: negative control.  < 0.01,  < 0.001, and  < 0.0001 vs. the NC group.

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