Aconitine Induces TRPV2-Mediated Ca²⁺ Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis

Figure 3

Aconitine induces intracellular Ca²⁺ overload by activating TRPV2. (a) The expression level of TRPV2 mRNA. (b, c) The protein expressions of TRPV2 and m/t-TRPV2. (d) The intracellular Ca²⁺ level in each group. NC: negative control; MC: model control; TL: tranilast; siTRPV2: siRNA of TRPV2; t-TRPV2: total TRPV2; m-TRPV2: membrane TRPV2.  < 0.05,  < 0.001, and  < 0.0001 vs. the NC group; ^### < 0.001 and ^#### < 0.0001 vs. the MC group.

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