Aconitine Induces TRPV2-Mediated Ca²⁺ Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis

Figure 4

Aconitine promotes TRPV2 expression and PM translocation by activating p38 MAPK signaling. (a) The expression level of TRPV2 mRNA. (b, c) The protein expressions of p38, p-p38, and TRPV2. (d) The intracellular Ca²⁺ level in each group. NC: negative control; MC: model control; SB: SB202190; t-TRPV2: total TRPV2; m-TRPV2: membrane TRPV2.  < 0.05 and  < 0.0001 vs. the NC group; ^## < 0.01, ^### < 0.001, and ^#### < 0.0001 vs. the MC group.

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