Aconitine Induces TRPV2-Mediated Ca²⁺ Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis

Figure 5

p38 MAPK inhibitor and TRPV2 inhibitor inhibit aconitine-induced intracellular Ca²⁺ overload and apoptosis. (a, b) The cell apoptosis rate of cardiomyocytes. (c, d) The protein expressions of cleaved caspase-3, p-p38, and m-TRPV2. (e) The intracellular Ca²⁺ content level in each group. NC: negative control; MC: model control; SB: SB202190; TL: tranilast; t-TRPV2: total TRPV2; m-TRPV2: membrane TRPV2. P < 0.05, P < 0.01,  < 0.001, and  < 0.0001 vs. the NC group; ^## < 0.01, ^### < 0.001, and ^#### < 0.0001 vs. the MC group.

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