Potential Interaction of Fresh Garlic with Metformin during Ischemia-Reperfusion Induced Cardiac Injury in Diabetic Rats

Figure 6

Histopathological slides of myocardial tissue. (a) Normal myocardial structure with integrity of membrane in nondiabetic control (normal control group). (b) Normal cardiac structure was observed in a section of the garlic-treated group. (c) The size of the cardiocytes appears to be reduced in the group treated with MET in this section. When contrasted with muscle tissue, the collagen tissue seems to be larger. Throughout the muscle tissue, there are scattered mononuclear inflammatory infiltrations. (d) The heart architecture of the group treated with MET and RGH is intact in this section. (e) Diabetic control section showing heart muscle with fibrovascular septae in between. The heart muscle appears to be in good condition. Between the heart muscle fibers, there are a few dispersed mononuclear inflammatory cells. (f) The cardiac architecture of diabetic animals treated with GH is intact in this section. The cardiocytes are placed haphazardly in some regions. The cardiocytes appear to be of normal size. (g) A section of the group that received MET showed myocardium and endocardium made up of cardiac muscle with fibrovascular septae in between. Between the heart muscle fibers, dispersed mononuclear inflammatory cells can also be observed. (h) Normal cardiac structure observed in the garlic and MET-treated groups.

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