Potential Interaction of Fresh Garlic with Metformin during Ischemia-Reperfusion Induced Cardiac Injury in Diabetic Rats

Figure 7

Histopathological studies of pancreatic tissue (long arrow shows centrally located ß cells and small arrow denotes peripherally positioned a cells). (a) The lobules of the pancreas are distinguished by septa of connective tissue in nondiabetic control group (normal control group). ß cells (80%) were present in the central islets, while a cells (20%) were mainly in the periphery. (b) The lobules of the pancreas are demarcated with the septum of connective tissue in the garlic-treated group in nondiabetic rats. Almost 70% is made up of central islet ß cells and 25% giant a cells in the periphery. (c) The lobule of the pancreas was divided by connective tissue septa in a section of the group treated with metformin (MET). The lobules are generally spherical Langerhans islets. Small ß-cell aggregates (70 percent, short arrow) with basophilic granules make up the heart of islet cells, while big a cells (25 percent, long arrow) make up the periphery. Thin-walled crowded capillaries intervene between these cells. (d) The lobules of the pancreas were demarcated clearly with septa of connective tissue in sections of the group treated with metformin and GH. ß cells make up 75% of the islets while 20% are a cells in the periphery. (e) Pancreatic lobules are divided by connective tissue septa in a diabetic control section. A large number of lobules have substantial patches of light-stained Langerhans islets. ß cells (60 percent, long arrow) with basophilic granules make up the heart of islet cells, while a cells (35 percent, short arrow) with eosinophilic granules make up the periphery. A few degraded beta cells can also be detected. (f) The lobules of the pancreas are distinguished by septa of connective tissue in a section of the garlic-treated group in diabetic rats. The ß cells make up 70% of islet cells while 25% of alpha cells are mainly located at the periphery. (g) The pancreatic lobules of animals treated with MET in diabetic rats have ß cells (70%) and 25% a cells in the periphery. (h) The center of islet cells in diabetic rats treated with MET and GH has 70% ß cells and 25% a cells in the periphery.

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