Qing-Kai-Ling Injection Acts Better Than Shen-Fu Injection in Enhancing the Antitumor Effect of Gefitinib in Resistant Non-Small Cell Lung Cancer Models

Figure 4

QKL/TRQ injection, not SF injection, enhanced the inhibition of the downstream signaling pathways of EGFR induced by gefitinib in vitro. (a) Western blot showing the expression of proteins related to the combination effect of gefitinib and QKL/SF in PC-9-PIK3CA-M and H1975 cell lines. (b) The effects of gefitinib and QKL/SF on EGFR, p-EGFR, AKT, p-AKT, ERK, and p-ERK protein expression in PC-9-PIK3CA-M cells and H1975 cells. (c) Western blot showing the expression of proteins related to the combination effect of gefitinib and TRQ in PC-9-PIK3CA-M and H1975 cell lines. (e) The effects of gefitinib and TRQ on EGFR, p-EGFR, AKT, p-AKT, ERK, and p-ERK protein expression in PC-9-PIK3CA and H1975 cells. Data are presented as the mean ± standard deviation of three independent experiments. vs. control. ^▲ vs. gefitinib alone. QKL, Qing-kai-ling injection; SF, Shen-fu injection; TRQ, Tan-re-qing injection.

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