Symptoms Based on Deficiency Syndrome in Traditional Chinese Medicine Might Be Predictor of Frailty in Elderly Community Dwellers

Table 6

Comparison of models with/without TCM symptoms based on deficiency syndrome for the risk prediction of frailty.

Indicators	Frailty cumulative components (“≥1” vs “＜1”)		Frailty cumulative components (“≥2” vs “＜2”)
	Reference model	New model	Reference model	New model
AUC (95% CI)	0.69 [0.66–0.71]	0.69 [0.67–0.72]	0.79 [0.76–0.83]	0.81 [0.78–0.85]
P value (AUC)	…	0.076	…	0.002
NRI events (%)	…	−44.4	…	−14.0
NRI nonevents (%)	…	52.5	…	55.4
NRI total (%)	…	8.14	…	41.4
P value (NRI)	…	0.175	…	0.016
IDI events (%)	…	0.0047	…	0.022
IDI nonevents (%)	…	0.0026	…	0.002
IDI total (%)	…	0.0073	…	0.024
P value (IDI)	…	0.056	…	0.041

Baseline model: age, education level, dietary habits, chronic obstructive pulmonary disease, diabetes, cerebral infarction, osteoporosis. New model: baseline model + selected TCM symptoms based on “five viscera” deficiency syndrome (cold limbs, lethargy and laziness in speaking and moving, weakness of lower limbs, slow movement, dry mouth and throat, glazed expression). AUC, area under the receiver-operating characteristic curve; CI, confidence interval; event, incident-specific frailty cumulative components; NRI, continuous net reclassification improvement; IDI, integrated discrimination improvement.