Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine

Figure 2

Analysis of gene expression based on |log2FC| ≥1 and FDR ≤0.05. (a) The bar graph showing the number of up- and downregulated DEGs. In LPS vs Ala (Ala group), 157 upregulated and 221 downregulated DEGs; 373 upregulated and 584 downregulated DEGs were found in LPS vs Deh (Deh group); and 754 upregulated and 964 downregulated DEGs were found in LPS vs Mix (Mix group). (b) Venn diagram showing the overlap of DEGs. Among these DEGs, only 4 DEGs coexpressed between the Ala group and Deh group; 48 DEGs coexpressed between Ala group and Mix group; and 634 DEGs coexpressed between Deh group and Mix group. A total of 247 significantly DEGs were shared by the Ala group, Deh group, and Mix group. (c) Heatmap showing the overlap of DEGs. The color means log2FC of the differential expression profiles. Blue represents genes with lower expression, and red represents genes with high expression.

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