Synergistic Regulation of Microglia Gene Expression by Natural Molecules in Herbal Medicine

Table 2

Some upregulated and downregulated genes list.

Gene ID	Gene symbol	Description	FC (LPS/NT)	FC (Ala/LPS)	FC (Deh/LPS)	FC (Mix/LPS)
Both Ala and Deh downregulated genes
16176	Il1β	Interleukin 1 beta	125.37	−9.04	−69.67	−867.61
12985	Csf3	Colony stimulating factor 3 (granulocyte)	349.71	−5.91	−19.37	−162.31
20306	Ccl7	Chemokine (C-C motif) ligand 7	38.05	−4.80	−15.56	−81.64
20296	Ccl2	Chemokine (C-C motif) ligand 2	15.89	−3.37	−7.81	−32.08
18126	Nos2	Nitric oxide synthase 2, inducible	11.63	−5.34	−28.10	−73.27
23962	Oasl2	2′-5′ Oligoadenylate synthetase-like 2	2.60	−13.91	−10.18	−54.89
16181	Il1rn	Interleukin 1 receptor antagonist	7.31	−1.24	−16.36	−42.59
21926	Tnf	Tumor necrosis factor	13.09	−1.87	−3.15	−8.05
15945	Cxcl10	Chemokine (C-X-C motif) ligand 10	8.63	−25.76	−6.03	−21.95
Both Ala and Deh upregulated genes
13198	Ddit3	DNA-damage inducible transcript 3	1.58	1.72	6.77	9.58
14630	Gclm	Glutamate-cysteine ligase, modifier subunit	1.23	3.33	2.52	6.45
228775	Trib3	Tribbles pseudokinase 3	1.31	4.65	2.10	5.56
76650	Srxn1	Sulfiredoxin 1 homolog (S. cerevisiae)	1.21	3.13	2.36	4.85
107503	Atf5	Activating transcription factor 5	1.13	3.86	2.12	4.84
67739	Slc48a1	Solute carrier family 48 (heme transporter), member 1	−1.17	2.40	2.67	4.62
12359	Cat	Catalase	−1.08	2.48	2.63	4.51
72017	Cyb5r1	Cytochrome b5 reductase 1	1.19	1.53	3.14	4.08
433375	Creg1	Cellular repressor of E1A-stimulated genes 1	−1.17	2.19	2.17	4.05
18412	Sqstm1	Sequestosome 1	1.68	1.60	3.16	4.00
233016	Blvrb	Biliverdin reductase B (flavin reductase (NADPH))	1.10	3.02	1.56	3.36
16889	Lipa	Lysosomal acid lipase A	−1.09	2.07	1.56	2.93
18477	Prdx1	Peroxiredoxin 1	1.19	2.31	1.62	2.68
Either Ala or Deh upregulated genes
12282	Hyou1	Hypoxia upregulated 1	1.01	−1.16	1.48	2.23
12491	Cd36	CD36 molecule	−1.03	2.79	−1.29	3.17
67951	Tubb6	Tubulin, beta 6 class V	1.21	1.09	−2.63	−3.41
13132	Dab2	Disabled 2, mitogen-responsive phosphoprotein	1.28	1.11	−2.92	−3.71
19241	Tmsb4x	Thymosin, beta 4, X chromosome	1.21	1.14	−1.96	−2.51
20250	Scd2	Stearoyl-Coenzyme A desaturase 2	−1.30	1.16	−2.82	−3.34
18793	Plaur	Plasminogen activator, urokinase receptor	2.64	1.21	−2.83	−3.65
11655	Alas1	Aminolevulinic acid synthase 1	2.11	1.21	−2.20	−2.43
71602	Myo1e	Myosin IE	1.73	1.24	−2.50	−3.14
11465	Actg1	Actin, gamma, cytoplasmic 1	1.35	1.25	−2.75	−3.72
20750	Spp1	Secreted phosphoprotein 1	1.22	1.25	−2.41	−1.75
12306	Anxa2	Annexin A2	1.04	1.25	−2.28	−2.11
11770	Fabp4	Fatty acid binding protein 4, adipocyte	1.77	1.28	−3.58	−5.02
326618	Tpm4	Tropomyosin 4	1.53	1.28	−1.68	−2.14
16956	Lpl	Lipoprotein lipase	−1.08	1.32	−2.74	−1.82
20620	Plk2	Polo like kinase 2	1.87	1.38	−2.09	−1.97
16985	Lsp1	Lymphocyte specific 1	−1.27	1.39	−2.33	−3.53
17381	Mmp12	Matrix metallopeptidase 12	2.06	1.51	−11.69	−4.98
16952	Anxa1	Annexin A1	1.22	1.59	−1.85	−2.18
29818	Hspb7	Heat shock protein family, member 7 (cardiovascular)	−1.04	1.62	−4.47	−4.06
18792	Plau	Plasminogen activator, urokinase	1.17	1.90	−3.70	−5.66