Cornel Iridoid Glycoside Ameliorated Alzheimer’s Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice

Figure 2

Effects of CIG on neuronal loss in the cerebral cortex of SAMP8 mice at young and aged SAMP8 mice. (a) Representative images of Nissl staining in the cerebral cortex of mice at 6 and 14 months of age. (b) Representative images of immunohistochemical staining for NeuN-labelled neurons in the cerebral cortex of mice at 6 and 14 months of age; scale bar = 100 μm. (c) Quantitative analysis of the number of NeuN-labelled neurons in the cerebral cortex of mice at 6 months of age and (d) at 14 months of age. Data are expressed as the mean ± S.E.M., n = 3 each group. , , and SAMP8 model group vs. SAMR1 control group; , , drug-treated SAMP8 groups vs. SAMP8 model group. NeuN; neuronal nuclei antigen.

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