Cornel Iridoid Glycoside Ameliorated Alzheimer’s Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice

Figure 3

Effects of CIG on demyelination in the corpus callosum of SAMP8 mice at young and aged SAMP8 mice. (a) Representative images of myelin basic protein (MBP) immunohistochemistry in the corpus callosum of SAMP8 mice at young and aged SAMP8 mice; scale bar = 100 μm. (b) Quantitative analysis of integrated optical density (IOD) for MBP immunohistochemistry at 6 months of age and (c) at 14 months of age. Data are expressed as the mean ± S.E.M., n = 3 each group. and , SAMP8 model group vs. SAMR1 control group; and , drug-treated SAMP8 groups vs. SAMP8 model group. IOD, integrated optical density.

(a)

(b)

(c)