Effects of a Chlorogenic Acid-Containing Herbal Medicine (LAS^NB) on Colon Cancer

Figure 4

Control and LAS^NB xenograft models. (a) Hematoxylin-eosin staining assay results are shown. Compared with the control group, the LAS^NB group showed increased colon cell apoptosis. (b) CD34, EGF, and VEGF expression and TUNEL-positive cells were assessed by immunohistochemistry in the tumor microenvironment. Magnification, 400x (). (c) Western blot results are shown. The expression of RTK kinase (EGF and VEGF), NF-κB proteins (NF-κB p65, NF-κB p50, and TGF-β), and MAPK (p-ERK and t-ERK) in the xenograft model (C1), CT26 cells (C2), and HCT15 cells (C3). ^∗, ^∗∗, and ^∗∗∗.

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(b)

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